Synchronous occurrence of gastrointestinal stromal tumors and other digestive tract malignancies in the elderly

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Synchronous occurrence of gastrointestinal stromal tumors and other digestive tract malignancies in the elderly

BACKGROUND/AIMS Elderly patients with gastrointestinal stromal tumors (GISTs) synchronous with other digestive tract malignancies have been rarely reported. In this study, clinicopathological characteristics were evaluated among elderly patients with GISTs with or without coexisting digestive tract malignancies. METHODS A total of 161 patients (≥65 years) were retrospectively reviewed at the ...

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Occurrence of second primary malignancies in patients with neuroendocrine tumors of the digestive tract and pancreas.

An increased association between neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NET) and other second primary malignancies has been suggested. We determined whether there is indeed an increased risk for second primary malignancies in GEP-NET patients compared with an age- and sex-matched control group of patients with identical malignancies. The series comprised 243 men a...

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Triple synchronous gastrointestinal malignancies: a rare occurrence.

Gastrointestinal cancer is common, and is a significant cause of morbidity and mortality. The synchronous occurrence of two different malignancies is not uncommon, but that of more than two malignancies is extremely rare. Such occurrences often pose diagnostic and therapeutic challenges. We report the case of an elderly man who was previously treated for gastric cancer 13 years ago, and who was...

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Gastrointestinal stromal tumors (GISTs) and second malignancies

Several evidences showed that patients with gastrointestinal stromal tumors (GISTs) develop additional malignancies. However, thorough incidence of second tumors remains uncertain as the possibility of a common molecular pathogenesis.A retrospective series of 128 patients with histologically proven GIST treated at our institution was evaluated. Molecular analysis of KIT and PDGFR-α genes was pe...

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Synchronous occurrence of colorectal adenocarcinoma and colonic gastrointestinal stromal tumor.

The synchronous occurrence of GIST and other primary gastrointestinal malignancies has been rarely reported. We report the case of an 84 year-old female who presented with a rectal blood loss. Total coloscopy revealed a stenotic lesion at sigmoid colon covered by endoscopically healthy mucosa and also a massive polypoid cecal mass. The patient underwent left subtotal colectomy and ileorectal J-...

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ژورنال

عنوان ژورنال: Oncotarget

سال: 2015

ISSN: 1949-2553

DOI: 10.18632/oncotarget.3108